Nutrition Research Institute
 Home | Research | Publications Donate Now

2012 | 2011 | 2010 and earlier | all

Download a copy of the latest published papers from NRI scientists:

Corbin, K. D., Abdelmalek, M. F., Spencer, M. D., da Costa, K. A., Galanko, J. A., Sha, W., Suzuki, A., Guy, C. D., Cardona, D. M., Torquati, A., Diehl, A. M., and Zeisel, S. H. (2013) Genetic signatures in choline and 1-carbon metabolism are associated with the severity of hepatic steatosis. FASEB J 27, 1674-1689  (PDF)

Bennett BJ, Orozco LD, et al. (2012) High-Resolution Association Mapping of Atherosclerosis Loci in Mice. Arterioscler Thromb Vasc Biol. 2012 Aug; 32 (8): 1790-8. 

Calabrese G, Bennett BJ, et al. (2012) Systems Genetic Analysis of Osteoblast-Lineage Cells. PLoS Genetics (In Press) 

Cheatham, C.L., Goldman, B.D., Fischer, L.M., da Costa, K-A, Reznick, S., Zeisel, S.H. (2012) Phosphatidylcholine supplementation in pregnant women consuming moderate choline diets does not enhance infant cognitive function:  a randomized double-blind placebo-controlled trial.  American Journal of Clinical Nutrition. doi: 10.3945/ajcn.112.037184.  (PDF)

Corbin, KD and Zeisel, SH. (2012) The Nutrigenetics and Nutrigenomics of the Dietary Requirement for Choline. In Bouchard, C and Ordovas, JM editors: Progress in Molecular Biology and Translational Science, Vol. 108, Burlington: Academic Press, 2012, pp. 159-177. 

Corbin, KD, Zeisel, SH. (2012) Choline Metabolism Provides Novel Insights into Non-alcoholic Fatty Liver Disease and its Progression. Curr Opin Gastroenterol. 28:159-165. PMID:22134222  (PDF)

Haines, RJ, Corbin, KD, Pendleton, LC, Eichler, DE. (2012) PKCα Phosphorylates a Novel Argininosuccinate Synthase Site at S328 During Calcium-Dependent Stimulation of eNOS in Vascular Endothelial Cells. J Biol Chem. 287: 26168–26176. PMID:22696221  (PDF)

Haines, RJ, Corbin, KD, Pendleton, LC, Meininger, CJ Eichler, DE. (2012) Insulin transcriptionally regulates argininosuccinate synthase to maintain vascular endothelial function. Biochem Biophys Res Commun. 421:9-14.  (PDF)

Johnson, A., Zeisel, S.H. (2012) Dietary choline and brain development. In International Handbook of Behavior, Diet and Nutrition, edited by Victor R. Preedy, Springer, New York, NY. 2089 – 2104. 

Johnson, A.R., Lao, S., Wang, T., Galanko, J.A., Zeisel, S.H. (2012) Choline dehydrogenase polymorphism rs12676 is a functional variation and is associated with changes in human sperm cell function. PLoS ONE. 7(4): e36047. PMID: 22558321.  (PDF)

LeBoeuf RC, Bennett BJ et al. (2012) Dissect complex traits using a high-resolution association mapping panel without genotyping: Hybrid Mouse Diversity Panel. Mammalian Genome Mamm Genome. 2012 Oct;23 (9-10):680-92. 

Lupu DS and Niculescu MD (2012) Perinatal Epigenetic Determinants of Cognitive and Metabolic Disorders. Aging and Disease 3  (PDF)

Niculescu MD, Lupu, DS and Craciunescu CN (2012) Perinatal manipulation of α-linolenic acid intake induces epigenetic changes in maternal and offspring livers. The FASEB Journal 27  (PDF)

Orozco LD, Bennett BJ, et al. (2012) Unraveling inflammatory responses through systems genetics and gene-environment interactions in mammalian macrophages. Cell. 2012 Oct 26; 151 (3):658-70. 

Plaisier CL, Bennett BJ, et al. (2012) Zbtb16 promotes brown adipogenesis and substrate utilization: potential effect on obesity. Nutrition and Diabetes (In Press) 

Richman, E.L., Kenfield, S.A., Stampfer, M.J., Giovannucci, E.L., Zeisel, S.H., Willett, W.C., Chan, J.M. (2012) Choline intake and risk of lethal prostate cancer:  incidence and survival.  American Journal of Clinical Nutrition.  96(4): 855 – 863.  PMID: 22952174.  (PDF)

Shuang Mei, Haihua Gu, Adam Ward, Xuefeng Yang, Huailan Guo, Ka He, Zhenqi Liu, and Wenhong Cao (2012) p38 Mitogen-activated Protein Kinase (MAPK) Promotes Cholesterol Ester Accumulation in Macrophages through Inhibition of Macroautophagy THE JOURNAL OF BIOLOGICAL CHEMISTRY VOL. 287, NO. 15, pp. 11761–11768  (PDF)

Teng, Y-W, Cerdena, I., Zeisel, S.H. (2012) Homocysteinemia in Mice with Genetic Betaine Homocysteine S-Methyltransferase Deficiency Is Independent of Dietary Folate Intake. The Journal of Nutrition. Doi:10.3945/jn.112.166835.  PMID: 23014492.  (PDF)

Teng, Y-W, Ellis, J.M., Coleman, R.A., Zeisel, S.H. (2012) Mouse Betaine-Homocysteine S-Methyltransferase deficiency reduces body fat via increasing energy expenditure and impairing lipid synthesis and enhancing glucose oxidation in white adipose tissue. e. Journal of Biological Chemistry. 287(20): 16187 - 98. PMID: 22362777.  (PDF)

Tsang, V., Fry,R., Niculescu, M., Saunders, J., Paul, D., Zeisel, S.H., Waalkes, M., Styblo, M., Drobna, Z. (2012) The epigenetic effects of a high prenatal folate intake in male mouse fetuses exposed in utero to arsenic toxicology and applied pharmacology. Toxicology and Applied Pharmacology. doi: 10.1016/j.taap.2012.08.22.  (PDF)

Yaling Yang, Owen R. Phillips, Eric Kan, Kathleen Sulik, Sarah Mattson, Edward P. Riley, Kenneth L. Jones, Colleen M. Adnams, Philip A. May, Mary J. O’Connor, Kathleen L. Narr, and Elizabeth R. Sowell. (2012) Callosal Thickness Reductions Relate to Facial Dysmorphology in Fetal Alcohol Spectrum Disorders. Alcoholism: Clinical and Experimental Research 36(5): 798-806 

Zeisel, S.H. (2012) Diet-Gene interactions underlie metabolic individuality and influence brain development: implications for clinical practice. Annuals of Nutrition and Metabolism. 60: 19 - 25.  (PDF)

Zeisel, S.H. (2012) Choline. In Modern Nutrition in Health and Disease, 11th Edition. Edited by C. Ross, B. Caballero, R. Cousins, K. Tucker, T. Ziegler, Lippincott Williams & Wilkins, Monkton, VT 416 - 426.  (PDF)

Zeisel, S.H. (2012) Metabolic crosstalk between choline/1-carbon metabolism and energy homeostatis.  Clinical Chemistry and Laboratory Medicine. doi:  10.1515/cclm-2012-0518.   PMID: 23072856.  (PDF)

Zeisel, S.H., Corbin, K. (2012) Choline. In 10th Edition of Present Knowledge of Nutrition, jointly edited by J.W. Erdman, I.A. MacDonald and S.H. Zeisel,Wiley-Blackwell, Hoboken, NJ. 659 – 681.  (PDF)

Zeisel, S.H., Waterland, R.A., Ordovas, J.M., Muoio, D., Jia, W., Fodor, A. (2012) Highlights of the 2012 Research Workshop:  Using Nutrigenomics and Metabolomics in Clinical Nutrition Research.  Journal of Parenteral and Enteral Nutrition. doi: 10.1177/0148607112462401.  (PDF)

C.M. Boustany-Kari, M.V. Jackson, C.P. Gibbons, A.G. Swick (2011) Leptin potentiates the anti-obesity effects of rimonabant European Journal of Pharmacology  Volume 658, Issues 2-3, 11: 270-276
 

Cheatham, C.L., Nerhammer, S., Asserhoj, M. Michaelsen, K., & Lauritzen, L. (2011) Effect of long- chain polyunsaturated fatty acid maternal supplementation during lactation on the executive function abilities of 7-year-olds. Lipids 46, 637-645 

Colombo, J., Carlson, S.E., Cheatham, C.L., Fitzgerald-Gustafson, K.M., Kepler, A., Schmeidler, T.  (2011) LCPUFA supplementation in infancy reduces heart rate and affects distribution of attention. Pediatric Research, 70, 1-5. 

Jack Dresser, Randall Starling, W. Gill Woodall, Paula Stanghetta, and Philip A. May (2011) A Field Trial of Alcohol Server Training for Prevention of Fetal Alcohol Spectrum Disorders Journal of Studies on Alcohol and Drugs 72(3): 490-496 

Knab, AM, Shanely, RA, Corbin, KD, Jin, F, Nieman, DC. (2011) A 45-min Vigorous Exercise Bout Increases Metabolic Rate for 14 hours. Med Sci Sports Exerc. 43(9):1643-1648. PMID:2131136  (PDF)

MD Niculescu, P Haggarty, Eds (2011) Nutrition in Epigenetics Wiley-Blackwell, Hoboken. 332 pages. ISBN: 978-0-470-95980-0. 

Niculescu M.D. (2011) Epigenetic transgenerational inheritance: Should obesity-prevention policies be reconsidered? Synesis J, 2, G18-26.  (PDF)

Niculescu, M. D. (2011) Nutritional Genomics: The Need for a Unified and Comprehensive Approach. J Nutrition Disorder Ther 1, e101  (PDF)

Niculescu, M. D., Lupu, D. S., and Craciunescu, C. N. (2011) Maternal alpha-linolenic acid availability during gestation and lactation alters the postnatal hippocampal development in the mouse offspring. Int J Dev Neurosci 29, 795-802  (PDF)

Niculescu, M.D. & Lupu, D.S. (2011) Nutritional influence on epigenetics and effects on longevity. Curr Opin Clin Nutr Metab Care Jan;14(1):35-40  (PDF)

Philip A. May and J. Phillip Gossage (2011) Maternal Risk Factors for Fetal Alcohol Spectrum Disorders: Not as Simple as it Might Seem. Alcohol Research and Health 34(1):15-26 

Philip A. May, Barbara G. Tabachnick, Luther K. Robinson, H. Eugene Hoyme, and J. Phillip Gossage (2011) Maternal Risk Factors Predicting Child Physical Characteristics and Dysmorphology in Fetal Alcohol Syndrome and Partial Fetal Alcohol Syndrome Drug and Alcohol Dependence doi:10,1016/j.drugaldep.2011.05.009 

Philip A. May, Daniela Fiorentino, Giovana Coraile, Wendy O. Kalberg, H. Eugene Hoyme, Alfredo S. Aragon, David Buckley, Chandra Stellavato, J. Phillip Gossage, Luther K. Robinson, Melanie Manning, and Mauro Ceccanti. (2011) Prevalence of Children with Fetal Alcohol Spectrum Disorders in Communities Near Rome, Italy: Rates Are Substantially Higher Than Previous Estimates. International Journal of Environmental Research and Public Health 8: 2331-2351 

Ralph P. Robinson , Jeremy A. Bartlett, Peter Bertinato, Andrew J. Bessire, Judith Cosgrove, Patrick M. Foley, Tara B. Manion, Martha L. Minich, Brenda Ramos, Matthew R. Reese, Theodore J. Schmahai, Andrew G. Swick , David A. Tess, Alfin Vaz, Angela Wolford (2011) Discovery of microsomal triglyceride transfer protein (MTP) inhibitorswith potential for decreased active metabolite load compared to dirlotapide Bioorg. and Med. Chem. Let.  21:4150-4154 

Tint, D., Anghel, M., Lupu, D. S., Fischer, L. M., and Niculescu, M. D. (2011) Low dose Flaxseed Oil Supplementation Alters the Fatty Acids Profile and the Progression of Metabolic Syndrome in Men without Adequate Medical Treatment. J Nutrition Disorder Ther S7, 1  (PDF)

Zeisel, S.H. (2011) What choline metabolism can tell us about the underlying mechanisms of fetal alcohol spectrum disorders.  Molecular Neurobiology.  doi 10.1007/s12035-011-8165-5.  (PDF)

Adams, K.M., Kohlmeier, M., Powell, M., Zeisel, S.H. (2010) Nutrition in Medicine: Nutrition education for medical students and residents.  Nutrition in Clinical Practice. 25(5):471-80.  (PDF)

Bryan, R.P., Asmar, M.M., Alderman, J.M., Alderman, E.A., Garland, A.L., Busby, W.H., Bodnar, W.M., Rusyn, I., Medoff, B., Tisch, R., Swenberg, J.A., Zeisel, S.H., Combs, T.P. (2010) Adiponectin lowers glucose production by increasing SOGA.  American Journal of Pathology.  177(40):  1936-1945.  PMCID:  PMC2947288.  (PDF)

Cheatham, C. L., Sesma, H. W., & Georgieff, M. K. (2010) The development of declarative memory in infants born preterm. In P.J. Bauer (Ed.), Advances in Child Development and Behavior, Volume 38 - Varieties of Early Experience: Implications for the Development of Declarative Memory in Infancy (pp. 111-135). London, U.K.: Elsevier.  

Cheatham, C.L., Larkina, M., Bauer, P.J., Toth, S., Cicchetti, D. (2010) Declarative memory in abused and neglected infants. Advances in Child Development and Behavior, Volume 38 - Varieties of Early Experience: Implications for the Development of Declarative Memory in Infancy (pp. 161-182). London, U.K.: Elsevier. 

Craciunescu, C.N., Johnson, A.R., Zeisel, S.H. (2010) Dietary choline reverses some, but not all effects of folate deficiency on neurogenesis and apoptosis in the fetal mouse brain. The Journal of Nutrition.    140:1162-6. PMCID: PMC2869500.  (PDF)

Fischer, L.M., da Costa, K-A, Kwock, L., Galanko, J., Zeisel, S.H. (2010) Dietary choline requirements of women:  effects of estrogen and genetic variation.   American Journal of Clinical Nutrition. 92(5):1113-19.  PMCID:  PMC2954445.  (PDF)

Fischer, L.M., daCosta, K-A, Galanko, J., Sha, W., Stephenson, B., Vick, J., Zeisel, S.H. (2010) Choline intake and genetic polymorphisms influence choline metabolite concentrations in human breast milk and plasma. American Journal of Clinical Nutrition. 92(2): 336-346.  PMCID:  PMC2904035.  (PDF)

Mehedint, M.G., Craciunescu, C.N., Zeisel, S.H. (2010) Maternal dietary choline deficiency alters angiogenesis in fetal mouse hippocampus. Proceedings of the National Academy of Sciences USA. 107(29): 12834-39.  PMCID:  PMC2919920.  (PDF)

Niculescu, M.D. (2010) Nutrients and Epigenetics (Choi & Friso eds). American Journal of Human Biology 22(6), 856-857.  (PDF)

Resseguie, M., da Costa, K-A, Galanko, J., Davis, I.J., Zeisel, S.H. (2010) Aberrant estrogen  regulation of PEMT results in choline deficiency-associated liver dysfunction.  Journal of Biological Chemistry. 286(2): 1649-58.  PMCID: PMC3020773.  (PDF)

Richard L. Elliott, Kimberly O. Cameron, Janice E. Chin, Jeremy A. Bartlett, Elena E. Beretta, Yue Chen, Paul Da Silva Jardine, Jeffrey S. Dubins, Melissa L. Gillaspy, Diane M. Hargrove, Amit S. Kalgutkar, Janet A. LaFlamme, Mary E. Lame, Kelly A. Martin, Tristan S. Maurer, Nancy A. Nardone, Robert M. Oliver, Dennis O. Scott, Dexue Sun, Andrew G. Swick, Catherine E. Trebino, Yingxin Zhang (2010) Discovery of N-Benzyl-2-[(4S)-4-(1H-indol-3-ylmethyl)-5-oxo-1-phenyl-4,5-dihydro-6H-[1,2,4]triazolo[4,3-a][1,5]benzodiazepin-6-yl]-N-isopropylacetamide, an Orally Active, Gut-Selective CCK1 Receptor Agonist for the Potential Treatment of Obesity Bioorg. and Med. Chem. Let.  20:6797-6801 

Spencer, M.D., Hamp, T.J., Reid, R.W., Fischer, L.M., Zeisel, S.H., Fodor, A.A. (2010) Association between composition of the human gastrointestinal microbiome and development of fatty liver with choline deficiency.  Gastroenterology.  doi:10.1053/j.gastro.2010.11.049.  (PDF)

Teng, Y-W, Zeisel, S.H. (2010) Choline in health and disease In Vitamins for the Prevention of Human Disease, Edited by W. Herrmann, R. Obeid, Walter De Gruyter GMBH & Co, Berlin, Germany. 599-612.  (PDF)

Zeisel, S.H. (2010) Choline:  An essential nutrient for public health. SCAN’S PULSE 29(3): 4 – 7.  (PDF)

Zeisel, S.H. (2010) Nutritional Genomics  Defining the dietary requirement and effects of choline.   The Journal of Nutrition.  531-534.  (PDF)

Zeisel, S.H. (2010) A Grand Challenge for Nutrigenomics.  Frontiers in Nutrigenomics. 1(2): 1-3.  (PDF)

Zeisel, S.H., Caudill, M.A. (2010) Choline.   Advances in Nutrition. 1: 46-48.  (PDF)

Zhang, S., Barros, S. P., Niculescu, M. D., Moretti, A. J., Preisser, J. S., and Offenbacher, S. (2010) Alteration of PTGS2 promoter methylation in chronic periodontitis. J Dent Res 89, 133-137  (PDF)

Craciunescu, C. N., Niculescu, M. D., Guo, Z., Johnson, A. R., Fischer, L., and Zeisel, S. H. (2009) Dose response effects of dermally applied diethanolamine on neurogenesis in fetal mouse hippocampus and potential exposure of humans. Toxicol Sci 107, 220-226  (PDF)

Niculescu, M. D., and Lupu, D. S. (2009) High fat diet-induced maternal obesity alters fetal hippocampal development. Int J Dev Neurosci 27, 627-633  (PDF)

Tint, D., Cocuz, M. E., Ortan, O. F., Niculescu, M. D., and Radoi, M. (2009) Cardiac involvement in trichinellosis: a case of left ventricular thrombosis. Am J Trop Med Hyg 81, 313-316  (PDF)

Niculescu, M.D., Zeisel, S.H. (2008) Choline and Neural Development. In Nutrition in the Prevention and Treatment of Disease, 2nd Edition (Coulston, A. and Boushey, C., Eds.) Elsevier Inc., Boston, pp. 241-251. 

Bidulescu, A.,Chambless, L.E., Seiga-Riz, A.M., Zeisel, S.H., Heiss, G. (2007) Usual choline and betaine dietary intake and incident coronary heart disease: the Atherosclerosis Risk in Communities (ARIC) Study. BMC Cardiovascular Disorders DOI:10.1186/1471-2261-7-20.  (PDF)

Fischer, L., da Costa, K., Kwock, L., Stewart, P., Lu, T., Stabler, S., Allen, R., Zeisel, S.H. (2007) Sex and menopausal status influence human dietary requirements for the nutrient choline. American Journal of Clinical Nutrition 85:1275-1285.  (PDF)

Niculescu, M., Wu, R., Guo, Z.,da Costa, K-A., Zeisel, S.H. (2007) Diethanolamine alters proliferation and choline metabolism in mouse neural procursor cells. Toxicology Sciences 96(2): 321-326.  (PDF)

Niculescu, M.,da Costa, K-A., Fischer, L., Zeisel, S.H. (2007) Lymphocyte gene expression in subjects fed low-choline diet differs between those who develop organ dysfunction and those who do not. American Journal of Clinical Nutrition 86: 230-239.  (PDF)

Resseguie, M., Song, J., Niculescu, M., da Costa, K-A., Randall, T., Zeisel, S.H (2007) Phosphatidylethanolamine N-methyltransferase (PEMT) gene expression is induced by estrogen in human and mouse primary hepatocytes. FASEB Journal DOI: 10.1096/fj.07-8227com.  (PDF)

Steck, S., Gammon, M., Hebert, J., Wall, D., Zeisel, S.H. (2007) GSTM1, GSTT1, GSTP1, GSTA1 polymorphisms and urinary isothiocyanate metabolites following broccoli consumption in humans. Journal of Nutrition 137: 904-909.  (PDF)

Zeisel, S.H (2007) Gene response elements, genetic polymorphisms and epigenetics influence the human dietary requirement for choline. IUBMB Life 59(6): 380-387.  (PDF)

Zeisel, S.H. (2007) Nutrigenomics and metabolomics will change clinical nutrition and public health practice: insights from studies on dietary requirements of choline. American Journal of Clinical Nutrition 86: 542-548.  (PDF)

da Costa, K. A., Kozyrez, O., Song, J., Galanko, J., Fischer, L., Zeisel, S.H. (2006) Common genetic polymorphisms affect the human requirement for the nutrient choline. FASEB Journal 20: 1336-1344.  (PDF)

Niculescu, M., Craciunescu, C., Zeisel, S.H. (2006) Dietary choline deficiency alters global and gene-specific DNA methylation in the developing hippocampus of mouse fetal brains. FASEB Journal 20:43-49  (PDF)

Niculescu, M., Pop, E., Fischer, L., Zeisel, S.H. (2006) Dietary isoflavones differentially induce gene expression changes in lymphocytes from postmenopausal women who form equol as compared to those who do not. Journal of Nutritional Biochemistry DOI: 10.1016/j.jnutbio2006.06.002.  (PDF)

Zeisel, S.H. (2006) The fetal origins of memory: the role of dietary choline in optimal brain development. The Journal of Pediatrics DOI: 10.1016/j.jpeds.2006.06.065  (PDF)

Kohlmeier, M., da Costa, K-A., Fischer, L., Zeisel, S.H. (2005) Genetic variation of folate-mediated one-carbon transfer pathway predicts susceptibility to choline deficiency in humans. Proceedings of the National Academy of Sciences USA 44:16025-16030.  (PDF)

Florence F. Rouseotte, Kathleen K. Sulik, Sarah N. Mattson, Edward P. Riley, Kennneth L. Jones, Colleen M. Adnams, Philip A. May, Mary J. O”Connor, Kathleen L. Karr, and Elizabeth R. Sowell () Regional Brain Volume Reductions Relate to Facial Dysmorphology and Neuro-cognitive Function in Fetal Alcohol Spectrum Disorders Human Brain Mapping 33:926-937