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Download a copy of the latest published papers from NRI scientists:

C.M. Boustany-Kari, M.V. Jackson, C.P. Gibbons, A.G. Swick (2011) Leptin potentiates the anti-obesity effects of rimonabant European Journal of Pharmacology  Volume 658, Issues 2-3, 11: 270-276
 

Cheatham, C.L., Nerhammer, S., Asserhoj, M. Michaelsen, K., & Lauritzen, L. (2011) Effect of long- chain polyunsaturated fatty acid maternal supplementation during lactation on the executive function abilities of 7-year-olds. Lipids 46, 637-645 

Colombo, J., Carlson, S.E., Cheatham, C.L., Fitzgerald-Gustafson, K.M., Kepler, A., Schmeidler, T.  (2011) LCPUFA supplementation in infancy reduces heart rate and affects distribution of attention. Pediatric Research, 70, 1-5. 

Jack Dresser, Randall Starling, W. Gill Woodall, Paula Stanghetta, and Philip A. May (2011) A Field Trial of Alcohol Server Training for Prevention of Fetal Alcohol Spectrum Disorders Journal of Studies on Alcohol and Drugs 72(3): 490-496 

Niculescu M.D. (2011) Epigenetic transgenerational inheritance: Should obesity-prevention policies be reconsidered? Synesis J, 2, G18-26. 

Niculescu, M.D. & Lupu, D.S. (2011) Nutritional influence on epigenetics and effects on longevity. Curr Opin Clin Nutr Metab Care Jan;14(1):35-40 

Philip A. May and J. Phillip Gossage (2011) Maternal Risk Factors for Fetal Alcohol Spectrum Disorders: Not as Simple as it Might Seem. Alcohol Research and Health 34(1):15-26 

Philip A. May, Barbara G. Tabachnick, Luther K. Robinson, H. Eugene Hoyme, and J. Phillip Gossage (2011) Maternal Risk Factors Predicting Child Physical Characteristics and Dysmorphology in Fetal Alcohol Syndrome and Partial Fetal Alcohol Syndrome Drug and Alcohol Dependence doi:10,1016/j.drugaldep.2011.05.009 

Philip A. May, Daniela Fiorentino, Giovana Coraile, Wendy O. Kalberg, H. Eugene Hoyme, Alfredo S. Aragon, David Buckley, Chandra Stellavato, J. Phillip Gossage, Luther K. Robinson, Melanie Manning, and Mauro Ceccanti. (2011) Prevalence of Children with Fetal Alcohol Spectrum Disorders in Communities Near Rome, Italy: Rates Are Substantially Higher Than Previous Estimates. International Journal of Environmental Research and Public Health 8: 2331-2351 

Ralph P. Robinson , Jeremy A. Bartlett, Peter Bertinato, Andrew J. Bessire, Judith Cosgrove, Patrick M. Foley, Tara B. Manion, Martha L. Minich, Brenda Ramos, Matthew R. Reese, Theodore J. Schmahai, Andrew G. Swick , David A. Tess, Alfin Vaz, Angela Wolford (2011) Discovery of microsomal triglyceride transfer protein (MTP) inhibitorswith potential for decreased active metabolite load compared to dirlotapide Bioorg. and Med. Chem. Let.  21:4150-4154 

Zeisel, S.H. (2011) What choline metabolism can tell us about the underlying mechanisms of fetal alcohol spectrum disorders.  Molecular Neurobiology.  doi 10.1007/s12035-011-8165-5. 

Adams, K.M., Kohlmeier, M., Powell, M., Zeisel, S.H. (2010) Nutrition in Medicine: Nutrition education for medical students and residents.  Nutrition in Clinical Practice. 25(5):471-80. 

Bryan, R.P., Asmar, M.M., Alderman, J.M., Alderman, E.A., Garland, A.L., Busby, W.H., Bodnar, W.M., Rusyn, I., Medoff, B., Tisch, R., Swenberg, J.A., Zeisel, S.H., Combs, T.P. (2010) Adiponectin lowers glucose production by increasing SOGA.  American Journal of Pathology.  177(40):  1936-1945.  PMCID:  PMC2947288. 

Cheatham, C. L., Sesma, H. W., & Georgieff, M. K. (2010) The development of declarative memory in infants born preterm. In P.J. Bauer (Ed.), Advances in Child Development and Behavior, Volume 38 - Varieties of Early Experience: Implications for the Development of Declarative Memory in Infancy (pp. 111-135). London, U.K.: Elsevier.  

Cheatham, C.L., Larkina, M., Bauer, P.J., Toth, S., Cicchetti, D. (2010) Declarative memory in abused and neglected infants. Advances in Child Development and Behavior, Volume 38 - Varieties of Early Experience: Implications for the Development of Declarative Memory in Infancy (pp. 161-182). London, U.K.: Elsevier. 

Craciunescu, C.N., Johnson, A.R., Zeisel, S.H. (2010) Dietary choline reverses some, but not all effects of folate deficiency on neurogenesis and apoptosis in the fetal mouse brain. The Journal of Nutrition.    140:1162-6. PMCID: PMC2869500. 

Fischer, L.M., da Costa, K-A, Kwock, L., Galanko, J., Zeisel, S.H. (2010) Dietary choline requirements of women:  effects of estrogen and genetic variation.   American Journal of Clinical Nutrition. 92(5):1113-19.  PMCID:  PMC2954445. 

Fischer, L.M., daCosta, K-A, Galanko, J., Sha, W., Stephenson, B., Vick, J., Zeisel, S.H. (2010) Choline intake and genetic polymorphisms influence choline metabolite concentrations in human breast milk and plasma. American Journal of Clinical Nutrition. 92(2): 336-346.  PMCID:  PMC2904035. 

Mehedint, M.G., Craciunescu, C.N., Zeisel, S.H. (2010) Maternal dietary choline deficiency alters angiogenesis in fetal mouse hippocampus. Proceedings of the National Academy of Sciences USA. 107(29): 12834-39.  PMCID:  PMC2919920. 

Niculescu, M.D. (2010) Nutrients and Epigenetics (Choi & Friso eds). American Journal of Human Biology 22(6), 856-857. 

Resseguie, M., da Costa, K-A, Galanko, J., Davis, I.J., Zeisel, S.H. (2010) Aberrant estrogen  regulation of PEMT results in choline deficiency-associated liver dysfunction.  Journal of Biological Chemistry. 286(2): 1649-58.  PMCID: PMC3020773. 

Richard L. Elliott, Kimberly O. Cameron, Janice E. Chin, Jeremy A. Bartlett, Elena E. Beretta, Yue Chen, Paul Da Silva Jardine, Jeffrey S. Dubins, Melissa L. Gillaspy, Diane M. Hargrove, Amit S. Kalgutkar, Janet A. LaFlamme, Mary E. Lame, Kelly A. Martin, Tristan S. Maurer, Nancy A. Nardone, Robert M. Oliver, Dennis O. Scott, Dexue Sun, Andrew G. Swick, Catherine E. Trebino, Yingxin Zhang (2010) Discovery of N-Benzyl-2-[(4S)-4-(1H-indol-3-ylmethyl)-5-oxo-1-phenyl-4,5-dihydro-6H-[1,2,4]triazolo[4,3-a][1,5]benzodiazepin-6-yl]-N-isopropylacetamide, an Orally Active, Gut-Selective CCK1 Receptor Agonist for the Potential Treatment of Obesity Bioorg. and Med. Chem. Let.  20:6797-6801 

Spencer, M.D., Hamp, T.J., Reid, R.W., Fischer, L.M., Zeisel, S.H., Fodor, A.A. (2010) Association between composition of the human gastrointestinal microbiome and development of fatty liver with choline deficiency.  Gastroenterology.  doi:10.1053/j.gastro.2010.11.049. 

Teng, Y-W, Zeisel, S.H. (2010) Choline in health and disease In Vitamins for the Prevention of Human Disease, Edited by W. Herrmann, R. Obeid, Walter De Gruyter GMBH & Co, Berlin, Germany. 599-612. 

Zeisel, S.H. (2010) Choline:  An essential nutrient for public health. SCAN’S PULSE 29(3): 4 – 7. 

Zeisel, S.H. (2010) Nutritional Genomics  Defining the dietary requirement and effects of choline.   The Journal of Nutrition.  531-534. 

Zeisel, S.H. (2010) A Grand Challenge for Nutrigenomics.  Frontiers in Nutrigenomics. 1(2): 1-3. 

Zeisel, S.H., Caudill, M.A. (2010) Choline.   Advances in Nutrition. 1: 46-48. 

Bidulescu, A.,Chambless, L.E., Seiga-Riz, A.M., Zeisel, S.H., Heiss, G. (2007) Usual choline and betaine dietary intake and incident coronary heart disease: the Atherosclerosis Risk in Communities (ARIC) Study. BMC Cardiovascular Disorders DOI:10.1186/1471-2261-7-20.  (PDF)

Fischer, L., da Costa, K., Kwock, L., Stewart, P., Lu, T., Stabler, S., Allen, R., Zeisel, S.H. (2007) Sex and menopausal status influence human dietary requirements for the nutrient choline. American Journal of Clinical Nutrition 85:1275-1285.  (PDF)

Niculescu, M., Wu, R., Guo, Z.,da Costa, K-A., Zeisel, S.H. (2007) Diethanolamine alters proliferation and choline metabolism in mouse neural procursor cells. Toxicology Sciences 96(2): 321-326.  (PDF)

Niculescu, M.,da Costa, K-A., Fischer, L., Zeisel, S.H. (2007) Lymphocyte gene expression in subjects fed low-choline diet differs between those who develop organ dysfunction and those who do not. American Journal of Clinical Nutrition 86: 230-239.  (PDF)

Resseguie, M., Song, J., Niculescu, M., da Costa, K-A., Randall, T., Zeisel, S.H (2007) Phosphatidylethanolamine N-methyltransferase (PEMT) gene expression is induced by estrogen in human and mouse primary hepatocytes. FASEB Journal DOI: 10.1096/fj.07-8227com.  (PDF)

Steck, S., Gammon, M., Hebert, J., Wall, D., Zeisel, S.H. (2007) GSTM1, GSTT1, GSTP1, GSTA1 polymorphisms and urinary isothiocyanate metabolites following broccoli consumption in humans. Journal of Nutrition 137: 904-909.  (PDF)

Zeisel, S.H (2007) Gene response elements, genetic polymorphisms and epigenetics influence the human dietary requirement for choline. IUBMB Life 59(6): 380-387.  (PDF)

Zeisel, S.H. (2007) Nutrigenomics and metabolomics will change clinical nutrition and public health practice: insights from studies on dietary requirements of choline. American Journal of Clinical Nutrition 86: 542-548.  (PDF)

da Costa, K. A., Kozyrez, O., Song, J., Galanko, J., Fischer, L., Zeisel, S.H. (2006) Common genetic polymorphisms affect the human requirement for the nutrient choline. FASEB Journal 20: 1336-1344.  (PDF)

Niculescu, M., Craciunescu, C., Zeisel, S.H. (2006) Dietary choline deficiency alters global and gene-specific DNA methylation in the developing hippocampus of mouse fetal brains. FASEB Journal 20:43-49  (PDF)

Niculescu, M., Pop, E., Fischer, L., Zeisel, S.H. (2006) Dietary isoflavones differentially induce gene expression changes in lymphocytes from postmenopausal women who form equol as compared to those who do not. Journal of Nutritional Biochemistry DOI: 10.1016/j.jnutbio2006.06.002.  (PDF)

Zeisel, S.H. (2006) The fetal origins of memory: the role of dietary choline in optimal brain development. The Journal of Pediatrics DOI: 10.1016/j.jpeds.2006.06.065  (PDF)

Kohlmeier, M., da Costa, K-A., Fischer, L., Zeisel, S.H. (2005) Genetic variation of folate-mediated one-carbon transfer pathway predicts susceptibility to choline deficiency in humans. Proceedings of the National Academy of Sciences USA 44:16025-16030.  (PDF)