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Download a copy of the latest published papers from NRI scientists:

Bidulescu, A.,Chambless, L.E., Seiga-Riz, A.M., Zeisel, S.H., Heiss, G. (2007) Usual choline and betaine dietary intake and incident coronary heart disease: the Atherosclerosis Risk in Communities (ARIC) Study. BMC Cardiovascular Disorders DOI:10.1186/1471-2261-7-20. (PDF)

Fischer, L., da Costa, K., Kwock, L., Stewart, P., Lu, T., Stabler, S., Allen, R., Zeisel, S.H. (2007) Sex and menopausal status influence human dietary requirements for the nutrient choline. American Journal of Clinical Nutrition 85:1275-1285. (PDF)

Niculescu, M., Wu, R., Guo, Z.,da Costa, K-A., Zeisel, S.H. (2007) Diethanolamine alters proliferation and choline metabolism in mouse neural procursor cells. Toxicology Sciences 96(2): 321-326. (PDF)

Niculescu, M.,da Costa, K-A., Fischer, L., Zeisel, S.H. (2007) Lymphocyte gene expression in subjects fed low-choline diet differs between those who develop organ dysfunction and those who do not. American Journal of Clinical Nutrition 86: 230-239. (PDF)

Resseguie, M., Song, J., Niculescu, M., da Costa, K-A., Randall, T., Zeisel, S.H (2007) Phosphatidylethanolamine N-methyltransferase (PEMT) gene expression is induced by estrogen in human and mouse primary hepatocytes. FASEB Journal DOI: 10.1096/fj.07-8227com. (PDF)

Steck, S., Gammon, M., Hebert, J., Wall, D., Zeisel, S.H. (2007) GSTM1, GSTT1, GSTP1, GSTA1 polymorphisms and urinary isothiocyanate metabolites following broccoli consumption in humans. Journal of Nutrition 137: 904-909. (PDF)

Zeisel, S.H (2007) Gene response elements, genetic polymorphisms and epigenetics influence the human dietary requirement for choline. IUBMB Life 59(6): 380-387. (PDF)

Zeisel, S.H. (2007) Nutrigenomics and metabolomics will change clinical nutrition and public health practice: insights from studies on dietary requirements of choline. American Journal of Clinical Nutrition 86: 542-548. (PDF)

da Costa, K. A., Kozyrez, O., Song, J., Galanko, J., Fischer, L., Zeisel, S.H. (2006) Common genetic polymorphisms affect the human requirement for the nutrient choline. FASEB Journal 20: 1336-1344. (PDF)

Niculescu, M., Craciunescu, C., Zeisel, S.H. (2006) Dietary choline deficiency alters global and gene-specific DNA methylation in the developing hippocampus of mouse fetal brains. FASEB Journal 20:43-49 (PDF)

Niculescu, M., Pop, E., Fischer, L., Zeisel, S.H. (2006) Dietary isoflavones differentially induce gene expression changes in lymphocytes from postmenopausal women who form equol as compared to those who do not. Journal of Nutritional Biochemistry DOI: 10.1016/j.jnutbio2006.06.002. (PDF)

Zeisel, S.H. (2006) The fetal origins of memory: the role of dietary choline in optimal brain development. The Journal of Pediatrics DOI: 10.1016/j.jpeds.2006.06.065 (PDF)

Kohlmeier, M., da Costa, K-A., Fischer, L., Zeisel, S.H. (2005) Genetic variation of folate-mediated one-carbon transfer pathway predicts susceptibility to choline deficiency in humans. Proceedings of the National Academy of Sciences USA 44:16025-16030. (PDF)