Sergey Krupenko, PhD
- The mechanism of discrimination between oxidized and reduced coenzyme in the aldehyde dehydrogenase domain of Aldh1l1
- JNK1/2 regulate Bid by direct phosphorylation at Thr59 in response to ALDH1L1
- A novel tumor suppressor function of glycine N-methyltransferase is independent of its catalytic activity but requires nuclear localization
- Activation of p21-Dependent G1/G2 Arrest in the Absence of DNA Damage as an Antiapoptotic Response to Metabolic Stress
- Rho GTPases RhoA and Rac1 mediate effects of dietary folate on metastatic potential of A549 cancer cells through the control of cofilin phosphorylation
- Molecular mechanisms underlying the potentially adverse effects of folate
- ALDH1L1 inhibits cell motility via dephosphorylation of cofilin by PP1 and PP2A
- Phylogeny and evolution of aldehyde dehydrogenase-homologous folate enzymes
- ALDH1L2 is the mitochondrial homolog of 10-formyltetrahydrofolate dehydrogenase
- Acyl carrier protein-specific 4′-phosphopantetheinyl transferase activates 10-formyltetrahydrofolate dehydrogenase
Sergey A. Krupenko, PhD, joined the UNC Nutrition Research Institute in 2014. Dr. Krupenko’s research focuses on vitamin folate and its role in liver function and cancer disease. His goal is to understand how we can fight cancer by controlling the diet and nutrient supplements. “There are molecular strings in the human organism, which can be pulled by right combinations of nutrients to activate resistance to tumor formation or to slow down cancer development. We have to identify these links and make them work,” he said. Dr. Krupenko has received his Bachelor’s Degree in Biochemistry from Byelorussian State University and PhD in Biochemistry at the Byelorussian Academy of Sciences. Before joining the NRI, he was a faculty member in the Department of Biochemistry, Vanderbilt University School of Medicine and in the Department of Biochemistry and Molecular Biology, Medical University of South Carolina. He has a joint appointment as a Professor of Nutrition at the Gillings School of Global Public Health, UNC-Chapel Hill.
Research Technician, Sergey Krupenko Lab
Claire Gates received Bachelor's degrees in Biology, with a concentration in cellular physiology, and Chemistry from UNCC in 2019. Her previous research focused on the elucidation and characterization of pathways involved in bacterial glycan synthesis. She is currently serving as a research technician in the Sergey Krupenko group, who are interested in the influence of folate on liver function and carcinogenesis. She hopes to begin her PhD in Biochemistry in 2020.
Graduate Student, S. Zeisel Labpaulese@live.unc.edu
Evan Paules joined the NRI in August 2016 as a doctoral student in the Nutrition Department. He completed his undergraduate program at Rider University
in Lawrenceville, NJ. He received his BS in 2016 with a double major in Biochemistry and Behavioral Neuroscience. His research interests include folate metabolism with relation to its role within the central nervous system, as well as cellular homeostasis. Evan was a 4-year member of Rider University’s Division 1 swim team.
Jaspreet Sharma, PhD
Postdoctoral Research Associate, S. Krupenko Labsharmaj@email.unc.edu
Jaspreet Sharma joined the NRI in the summer of 2017 in the S. Krupenko’s Lab to investigate the role of folate-metabolizing enzymes in cancer progression and metastasis. She received her PhD from the Graduate Program in the Department of Gastroenterology, PGIMER, Chandigarh (India). Her graduate studies focused on prevention of colon cancer by dietary supplements. She has received her postdoctoral training in the Department of Radiation Oncology at the University of Colorado, Denver, working on the receptor-mediating signaling in tumorigenesis.